Hybrid approach for treating patient with chronic thromboembolic pulmonary hypertension and extrinsic compression of left main coronary artery

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Nikolay M. Danilov, Madina B. Karabasheva, Olesya V. Sagaydak, Yuriy G. Matchin, Kirill V. Mershin, Irina E. Chazova
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Background ― Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare life-threatening form of pulmonary artery hypertension. CTEPH is potentially curable by performing surgical operation – pulmonary thrombendarteriectomy. Unfortunately, about 36% of patients with CTEPH are considered as inoperable because of different conditions including left main coronary artery compression syndrome (LMCS), caused by compression with delated pulmonary artery. Appropriate management of patients with CTEPH and LMCS remains unknown. Case report ― We report for the first time a case of a successful hybrid treatment of patient with CTEPH and LMCS. Due to high pulmonary vascular resistance (PVR) and LMCS (90% stenosis) the risk for pulmonary thrombendarteriectomy for patient was considered as high. The multidisciplinary team decided to start treatment with new method of treatment for patients with CTEPH – balloon pulmonary angioplasty. In 5 months 4 sessions of balloon pulmonary angioplasty were successfully performed. In a follow-up mean pulmonary artery pressure decreased from 57 to 37 mm Hg, PVR decreased from 20 to 7 WU. Coronary angiography showed no compression of left main coronary artery. The diameter of pulmonary artery decreased from 4.2 to 3.6 cm. Patient was reconsidered as operable and transferred to a surgical unit for pulmonary thrombendarteriectomy. Conclusion ― Effective balloon pulmonary angioplasty can lead to regression of left main compression syndrome in CTEPH patients. Balloon pulmonary angioplasty can be a “bridge-treatment” to pulmonary thrombendarteriectomy in patients with high operation risk.
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Danilov NM, Karabasheva MB, Sagaydak OV, Matchin YG, Mershin KV, Chazova IE. Hybrid approach for treating patient with chronic thromboembolic pulmonary hypertension and extrinsic compression of left main coronary artery. Russian Open Medical Journal 2019; 8: e0407.


Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but life-threatening form of pulmonary artery hypertension (PAH). At the same time CTEPH is unique form of pulmonary hypertension (PH) due to it is potentially curable by performing surgical operation – pulmonary thrombendarteriectomy (PTE) [1].

Unfortunately, about 36% of patients with CTEPH are considered as inoperable [2] because of very high pulmonary vascular resistance (PVR), distal location of lesions and comorbidities [3, 4]. Sometimes patients have another very important contraindication – left main coronary compression syndrome (LMCS) caused by dilated pulmonary artery (PA). Nearly 80% of patients with severe pulmonary hypertension have pulmonary artery dilatation [5]. PA dilatation can lead to left main coronary artery (LMCA) extrinsic compression, causing coronary insufficiency, which is independent mortality risk factor in patients with PAH [6]. The incidence of LMCS is ranging from 5% to 44% in all patients with PAH [7, 8]. Considering only patients with CTEPH – true incidence of LMCS is still unknown.

Besides surgical treatment with PTE, there are two other treatment opportunities for patients with CTEPH: medical treatment and new method – balloon pulmonary angioplasty (BPA). But treating patient with CTEPH complicated by LMCA is a difficult task, as currently there is no approved treatment for patients with CTEPH and LMCS. Thus, not all of the “classical” strategies are pertinent. PTE is no recommended in this group due to high operation risks. PAH specific medical therapy with riociguat [9], as it remains the only approved medical treatment for CTEPH patients, in case of LMCS could lead to steal syndrome and thus, is also not recommended in PAH patients with LMCA.

Nowadays there exists a new proven method of treating inoperable CTEPH patients – balloon pulmonary angioplasty – it has shown improvements in patient’s hemodynamics and exercise capacity [10-12].

Though currently, the appropriate management of patients with CTEPH and LMCS remains unknown, BPA seems quite promising. BPA “fights” with very cause of LMCS – pulmonary hypertension. So we considered BPA as a useful instrument for our new strategy. In this case we report for the first time hybrid treatment strategy for patient with CTEPH, complicated by LMCA.


Case Report

A 61-year-old woman with severe dyspnea, chest discomfort on exertion and legs swelling was admitted to our PH department. She had chronic hip subluxation that limited her physical activity. By that time, she had 12-year disease anamnesis.

In 2003 patient experienced first episode of dyspnea but did not go to a doctor. Starting that time till 2008 her status was deteriorating. In 2008 due to severe dyspnea and low functional class she was admitted to the hospital where systolic pulmonary artery pressure was measured by transthoracic echocardiography for the first time: it was 112 mm Hg. Lung perfusion scintigraphy revealed multiple perfusion defects in both lungs. Following approved diagnostic algorithm, the diagnosis of CTEPH was revealed. Anticoagulation therapy by warfarin was prescribed immediately. From 2008 to 2015 the patient has taken therapy with warfarin and diuretic. In 2015 chest pain and discomfort on exertion, dyspnea at rest, legs and feet swelling appeared. By that time, due to weakness and severe dyspnea patient was confined to wheelchair. To clarify the diagnosis and choose therapy patient was referred to our PH department.

Standard PH diagnostic algorithm was performed. A 12-lead electrocardiogram (Figure 1) revealed sinus tachycardia and right bundle brunch block.


Figure 1. Electrocardiogram before treatment


Main laboratory test results: hemoglobin – 15.7 g/dl, RBC – 5.06х1012/l, cholesterol – 4.9 mmol/l, creatinine – 85 mkmol/dl, D-dimer – 1.34 μg/mL, BNP – 1250 ng/dL.

Transthoracic echocardiography showed enlargement of the right atrium area up to 34 sm2, right ventricle basal diameter was 4,8 sm and via apex view 6,0 sm, systolic PA pressure was 93 mmHg, tricuspid annular plane systolic excursion (TAPSE) was 1.4 sm, inferior vena cava (IVC) diameter was enlarged up to 2.6 sm with positive respiratory variation, main PA was significantly dilatated up to 4.2 sm. 

Patient underwent computed tomography (CT) angiography, which showed thrombosis of pulmonary artery branches (segmental occlusion of the left C4, C6, C9, C10 and right C6, C7 arteries). Furthermore, significant enlargement of the PA trunk and shortening of the distance between PA trunk and LMCA was observed.

Right heart catheter examination (RHC) showed mean pulmonary artery pressure (mPAP) 57 mmHg, cardiac output (CO) 2,6 l/min, pulmonary vascular resistance (PVR) 1,569 dyn/s/cm5 (20 WU). Pulmonary angiography showed thrombotic masses which narrowed both pulmonary arteries, predominantly proximal lesions in the upper lobes and distal lesions in the lower lobes.

Having in mind LMCS (due to CT angiography findings and chest discomfort complains) and high probability of coronary artery disease, coronary angiography was performed.

The coronary angiography showed short LMCA with angiographic excentric subtotal stenosis. There were no atherosclerotic changes or stenosis of other coronary arteries. To evaluate the severity and structure of the stenosis we performed intravascular ultrasound (IVUS). It was shown that the ostium of LMCA was narrowed down to 9 mm2 without evidence of underlying atherosclerosis – it was enlarged PA trunk that compressed LMCA. This stenosis though was not hemodynamically significant and there were no indications for endovascular treatment (Figure 2). 


Figure 2. Pulmonary angiography (a), coronary angiography (b) and intravascular ultrasound (c) before first BPA.


Patient was discussed on “Heart Team” meeting, which included cardiologist, cardiac surgeon, interventional specialist and CT-specialist. Proximal lesions are indication for surgical operation – PTE, but due to high level of PVR, narrowing of the LMCA and poor physical condition the procedure mortality risk was too high. Prescribing PAH specific therapy was also risky as combined with LMCA compression it could lead to steal syndrome. The “Heart Team” decision was, despite predominantly proximal lesions, to start treatment with balloon pulmonary angioplasty.

Within 5 months 4 BPA sessions were performed, 10 segmental arteries of both lungs and the main lower lobe artery were successfully treated (Figure 3). Control RHC showed significant improvement in hemodynamic parameters: reduction of mPAP from 57 to 47 mm Hg and PVR from 1569 dyn/s/cm5 (20 WU) to 911 dyn/s/cm5 (7 WU). Coronary angiography did not reveal LMCA compression and IVUS showed that the luminal area of LMCA enlarged from 9 to 12mm (Figure 3). We also observed BNP level dropping from 1250 to 150 ng/dL. All changes correlated with improvement of functional status – patient was able to refuse wheelchair and started walking by herself. All this time therapy with warfarin and diuretics have been continued.


Figure 3. Changes of pulmonary angiography (a), coronary angiography (b) and intravascular ultrasound (c) after BPA


However, after 4 BPA sessions the patient still had PH (mPAP-47 mmHg). After final BPA session pulmonary angiography showed that in the upper lobes and in the left lower lobe proximal thrombotic masses remained. The PTE operation risk was reconsidered as low and the patient was transferred to the surgical unit for performing PTE.

The standard PTE for CTEPH using intermittent circulatory arrest under deep hypothermia was performed. The operation was successful. After the operation mPAP was 32 mmHg and PVR was 401 dyn/s/cm5 (5 WO) (Table 1). Transthoracic echocardiography was repeated: right atrium area was 4 sm2, right ventricle basal diameter was 3.1 sm and via apex view 4.6 sm, systolic PA pressure was 55 mmHg, TAPSE was 2.0 sm, IVC diameter was within normal limits, main PA was 3.7 sm.


Table 1. Time course changes of hemodynamic parameters


Baseline (before first session)

After final BPA session

After PTE

Follow up

mean PAP, mm Hg

PVR, dyn/s/cm5

CO, l/min

CI, l/min*m2

SaO2, %

SvO2, %

























BPA, balloon pulmonary angioplasty; PTE, pulmonary thrombendarteriectomy; PAP, pulmonary artery pressure; PVR, pulmonary vascular resistance; CO, cardiac output; CI, cardiac index; SaO2, arterial blood saturation; SvO2, venous blood saturation.


The CT was repeated and showed improvement of perfusion in all operated areas (Figure 4) but left segmental artery C10 still had been occluded. After standard rehabilitation the patient functional status was dramatically improved, and she was discharged home.


Figure 4. Computer tomography before BPA (a), after all BPA sessions and after PTE C10 branch of left segmental artery is occlusived (c)


After 6 months she was admitted to our PH department for check-up. Patient’s functional status, transthoracic echocardiography, data of RHC had not revealed progression of the disease and there were still no indications for prescribing PAH therapy. Follow up is still continuing.



In 1957, Corday et al. first described LMCA compression by a dilated pulmonary artery in patients with PH [13]. There have been some reports regarding coronary artery compression by a dilated main pulmonary artery secondary to primary PH and congenital heart diseases, which may lead to sudden death due to malignant arrhythmia and left ventricular dysfunction [7]. The optimal management of LMCA compression in these patients is unknown because treatment of this condition is based on a limited number of case reports.

In 2001, Rich, et al reported the first two patients with PH whose extrinsic LMCA compression was treated by percutaneous insertion of an intracoronary stent [14]. Rich et al. believed that coronary angiography should be performed in all patients with PH presenting with effort angina or left ventricular dysfunction [14].

In our case LMCA compression due to IVUS data was not significant, thus there was no indication for stent implantation.

We recommend coronary angiography in every patient with CTEPH and any type of chest discomfort or dilatated pulmonary artery. If LMCA compression is not severe and endovascular treatment could be avoided all efforts should be directed towards reducing pulmonary pressure to decompress the LMCA. There are two options: PAH specific therapy and balloon pulmonary angioplasty. PAH therapy is not recommended because of possible steal syndrome. BPA is not contraindicated in patients with LMCA and is more preferable as it has demonstrated good hemodynamic results even after 2 sessions.

Here we for the first time report hybrid treatment strategy with BPA and PTE for patient with CTEPH, complicated by LMCA.



Our case demonstrated successful treatment of patient with severe CTEPH, high operation mortality risk and compression of LMCA as contraindication to standard PAH therapy.

PH specialists treating patient with PH and chest pain have to be alert about LMCA compression syndrome. In our case BPA sessions significantly decrease mPAP and PVR leading to reversing LMCA compression and symptoms relief.

“Heart team” consecutive treatment strategy starting with BPA converted inoperable form of CTEPH to operable form and made it possible to perform PTE.

We conclude, that this strategy may be considered in patients with high PTE operation risk due to modifiable factors (high PVR, high mPAP, LMCA compression) or for patients with contraindications for PAH-therapy.


Conflict of Interest

The authors declare that they have no conflict of interest.

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About the Authors: 

Nikolay M. Danilov – MD, DSc, Leading Researcher, Hypertension Department, National Medical Research Center of Cardiology, Moscow, Russia. https://orcid.org/0000-0001-9853-9087.
Madina B. Karabasheva – MD, Graduate Student, Hypertension Department, National Medical Research Center of Cardiology, Moscow, Russia. http://orcid.org/0000-0001-6734-4324.
Olesya V. Sagaydak – MD, PhD, Researcher, Hypertension Department, National Medical Research Center of Cardiology, Moscow, Russia. https://orcid.org/0000-0002-2534-8463.
Yuriy G. Matchin – MD, DSc, Chief of the Department of Endovascular Treatment, National Medical Research Center of Cardiology, Moscow, Russia. https://orcid.org/0000-0002-0200-852X.
Kirill V. Mershin – MD, PhD, Leading Researcher, Surgeon Department, National Medical Research Center of Cardiology, Moscow, Russia https://orcid.org/0000-0002-7256-0563.
Irina E. Chazova – MD, DSc, Professor, Academician of Russian Academy of Science, Chief of the Hypertension Department, National Medical Research Center of Cardiology, Moscow, Russia. https://orcid.org/0000-0002-9822-4357.

Received 24 September 2019, Revised 11 November 2019, Accepted 25 November 2019

© 2019, Danilov N.M., Karabasheva M.B., Sagaydak O.V., Matchin Y.G., Mershin K.V., Chazova I.E.
© 2019, Russian Open Medical Journal

Correspondence to Madina B. Karabasheva. E-mail: madi.karabasheva@yandex.ru.